Effect of EGF dosage forms on alkali burned corneal wound healing of mice

• Published in: Burns 1995-02, Vol.21 (1), p.7-10
• Main Authors: Gönül, B., Erdoǧan, D., Özoǧul, C., Koz, M., Babül, A., Celebi, N.
• Format: Article
• Language: English
• Subjects: Administration, Topical; Animals; Biological and medical sciences; Burns, Chemical - drug therapy; Cornea - drug effects; Cornea - pathology; Drug Carriers; Epidermal Growth Factor - administration & dosage; Epidermal Growth Factor - therapeutic use; Eye Burns - chemically induced; Eye Burns - drug therapy; Female; Injuries of the skin. Diseases of the skin due to physical agents; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Solutions; Traumas. Diseases due to physical agents; Wound Healing - drug effects
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/0305-4179(95)90773-S

The local treatment effects of EGF forms on alkali burned mice corneal wounds were identified. The corneal wounds were induced by 0.5 M NaOH solution on the corneal surfaces of the mice. The local epidermal growth factor solutions (100 ng/ml) and gel form in 0.2 per cent w w carbopol 940 (100 ng/ml) were dropped in 5 μl aliquots into the eye twice a day. The corneal wounds were measured for 15 days at 7-day intervals and examined histologically at the end of 15th day of the experimental period. The results indicated that topical epidermal growth factor treatment in solution improved the healing of alkali burned corneal wounds when compared with epidermal growth factor delivered in a polymer system.