Metabolic disposition of 2-phenylethylamine and the role of depression in methadone-dependent and detoxified patients

We have now postulated that differences in the innate capacity of individuals to synthesize, store and utilize biogenic amines may provide the biological basis for human abuse of narcotic and other drugs, and that these drugs are used in an apparent unconscious effort to self-medicate against an inh...

Full description

Saved in:
Bibliographic Details
Published in:Drug and alcohol dependence 1976-01, Vol.1 (4), p.295-303
Main Authors: Inwang, Edet E., Primm, Beny J., de L. Jones, Frank, Dekirmenjian, Haroutune, Davis, John M., Henderson, Cynthia T.
Format: Article
Language:English
Subjects:
Adult
Depression - physiopathology
Female
Heroin Dependence - rehabilitation
Humans
Male
Methadone - pharmacology
Methadone - therapeutic use
Phenethylamines - urine
Substance Withdrawal Syndrome - etiology
Substance Withdrawal Syndrome - urine
Substance-Related Disorders - complications
Substance-Related Disorders - etiology
Substance-Related Disorders - urine
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have now postulated that differences in the innate capacity of individuals to synthesize, store and utilize biogenic amines may provide the biological basis for human abuse of narcotic and other drugs, and that these drugs are used in an apparent unconscious effort to self-medicate against an inherent affective disorder. In this communication, we attempted a preliminary characterization of the narcotics withdrawal syndrome on biochemical and clinical parameters. Abstinence was found to be characterized by low urinary excretion of 2-phenylethylamine and depression. An indication for use of tricyclic drugs has been discussed.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(76)90025-9