Platelet monoamine oxidase and erythrocyte Catechol- o-Methyltransferase activity in alcoholism and controlled abstinence

This study substantiates previous reports that low platelet monoamine oxidase (MAO) activity is associated with alcoholism. Catechol- o-methyltransferase (COMT) activity in erythrocytes of alcoholics did not differ from that of controls. In 20 male alcoholics low platelet MAO activity was found duri...

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Bibliographic Details
Published in:Drug and alcohol dependence 1983-08, Vol.12 (1), p.85-91
Main Authors: Agarwal, O.P., Philippu, G., Milech, U., Ziemsen, B., Schrappe, O., Goedde, H.W.
Format: Article
Language:English
Subjects:
Adult
Alcoholism
Alcoholism - enzymology
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Blood Platelets - enzymology
Catechol O-Methyltransferase - blood
Chemical and Drug Induced Liver Injury - enzymology
Erythrocyte catechol- o-methyltransferase
Erythrocytes - enzymology
Female
Humans
Male
Medical sciences
Middle Aged
Monoamine Oxidase - blood
Platelet monoamine oxidase
Substance Withdrawal Syndrome - enzymology
Toxicology
Tryptamines - blood
Tyramine - blood
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Summary:This study substantiates previous reports that low platelet monoamine oxidase (MAO) activity is associated with alcoholism. Catechol- o-methyltransferase (COMT) activity in erythrocytes of alcoholics did not differ from that of controls. In 20 male alcoholics low platelet MAO activity was found during the first 3 days after hospitalization. The MAO activity increased in the next 2 weeks of abstinence and then tended to decrease again.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(83)90056-X