Intravenous self-administration of (−)-cathinone and 2-amino-1-(2,5-dimethoxy-4-methyl)phenylpropane in rhesus monkeys

The reinforcing effects of (−)-cathinone, a pharmacologically active ingredient of khat, and 2-amino-1-(2,5-dimethoxy-4-methyl)phenylpropane ((STP) (DOM)), a hallucinogenic psychotomimetic, were studied by intravenous self-administration experiments in rhesus monkeys. Among the experiments described...

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Bibliographic Details
Published in:Drug and alcohol dependence 1986-06, Vol.17 (2), p.135-141
Main Author: Yanagita, Tomoji
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Amphetamines - pharmacology
Animals
Applied sciences
Behavior, Animal - drug effects
Biological and medical sciences
Cathinone
Central Nervous System - drug effects
Cocaine - pharmacology
DOM
DOM 2,5-Dimethoxy-4-Methylamphetamine - pharmacology
Exact sciences and technology
Generalization, Stimulus
Injections, Intravenous
Macaca mulatta
Medical sciences
Neuropharmacology
Other techniques and industries
Pharmacology. Drug treatments
Progressive ratio
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Reinforcement, Psychology
Rhesus monkeys
Self Administration
STP
Substance-Related Disorders
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Summary:The reinforcing effects of (−)-cathinone, a pharmacologically active ingredient of khat, and 2-amino-1-(2,5-dimethoxy-4-methyl)phenylpropane ((STP) (DOM)), a hallucinogenic psychotomimetic, were studied by intravenous self-administration experiments in rhesus monkeys. Among the experiments described in this paper, the result of continuous self-administration of (−)-cathinone was briefly reported elsewhere. T. Yanagita, Studies on Cathinones, NIDA Research Monograph 27, Proceedings of 41st Annual Scientific Meeting of the Committee on Problems of Drug Dependence, 1979, pp. 326–327.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(86)90004-9