Effect of propylthiouracil on liver cell development in the male albino mouse: protective effect against ethanol-induced alterations

The aim of the present study is to analyze whether the addition of propylthiouracil reverts the influence of ethanol on the development of periportal and pericentral hepatocytes and their nuclei in male albino mice. Propylthiouracil-treated animals showed decreased cellular and nuclear areas when co...

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Published in:Drug and alcohol dependence 1988-02, Vol.21 (1), p.11-18
Main Authors: González-Reimers, C.Emilio, Santolaria-Fernández, Francisco J., González-Hernández, Tomás, Batista-López, Norberto, Gómez-Sirvent, J.Luis, del Mar Pérez-Delgado, M., Ferres-Torres, Romualdo
Format: Article
Language:English
Subjects:
alcoholic liver disease
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
ethanol
Ethanol - toxicity
hepatocyte area
Liver - drug effects
Liver - pathology
Male
Medical sciences
Mice
Oxygen Consumption - drug effects
propylthiouracil
Propylthiouracil - pharmacology
Toxicology
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Summary:The aim of the present study is to analyze whether the addition of propylthiouracil reverts the influence of ethanol on the development of periportal and pericentral hepatocytes and their nuclei in male albino mice. Propylthiouracil-treated animals showed decreased cellular and nuclear areas when compared with the control animals, except for the 180-day-old animals, whose pericentral cells and nuclei were greater than those of the controls and exhibited fatty infiltration. Pericentral hepatocytes and nuclei of the ethanol-fed animals showed an increase of their sizes, especially in 180-day-old animals. In contrast, hepatocyte and nuclear sizes of the animals treated with both propylthiouracil and ethanol were similar to those of the control group, suggesting a protective effect of propylthiouracil against the ethanol-induced alterations.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(88)90004-X