Biochemical resistance to development of morphine-dependence in rats: biogenic amines, its receptors and antibodies

The level of norepinephrine (NE), epinephrine (E) and dopamine (DA) in hypothalamus and blood plasma along with antibodies to NE, DA and serotonin (5-HT) and characteristics of α 1−, α 2-adrenergic, D 2-dopaminergic and S 2-serotoninergic receptors in synaptic brain membranes were studied in two gro...

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Bibliographic Details
Published in:Drug and alcohol dependence 1992-08, Vol.30 (3), p.289-292
Main Authors: Rusakov, Dimitrij Ju, Borisova, Elena V., Tronnikov, Sergey I., Kuznetzova, Marina N., Veretinskaya, Alla.G., Gamaleya, Natalia B., Sudakov, Sergey K.
Format: Article
Language:English
Subjects:
Animals
Antibodies - blood
Biogenic Amines - analysis
Biogenic Amines - immunology
Biological and medical sciences
Brain Chemistry
Cerebral Cortex - chemistry
Corpus Striatum - chemistry
dopamine
Dopamine - analysis
Dopamine - immunology
Drug addictions
epinephrine
Epinephrine - analysis
Epinephrine - immunology
genetic predisposition
Hypothalamus - chemistry
Male
Medical sciences
Morphine
morphine dependence
norepinephrine
Norepinephrine - analysis
Norepinephrine - immunology
Rats
Rats, Wistar
Receptors, Adrenergic - analysis
serotonin
Substance-Related Disorders - blood
Toxicology
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Summary:The level of norepinephrine (NE), epinephrine (E) and dopamine (DA) in hypothalamus and blood plasma along with antibodies to NE, DA and serotonin (5-HT) and characteristics of α 1−, α 2-adrenergic, D 2-dopaminergic and S 2-serotoninergic receptors in synaptic brain membranes were studied in two groups of rats predisposed or resistant to the formation of physical morphine dependence. The resistant animals were characterized by a significant elevation of DA levels in blood plasma, elevation of antibodies to NE, and by higher concentration of α 2-adrenergic receptors in the brain cortex and of D 2-receptors in striatum. The affinity of D 2-receptors to dopamine in resistant rats also was higher than in predisposed animals. The other parameters studied did not differ significantly between the two groups. These findings suggest that the increased activity of DA and NE neurotransmitter systems can be a cause for the genetic resistance of some individuals among Wistar rats to the formation of physical dependence on morphine.
ISSN:0376-8716
1879-0046
DOI:10.1016/0376-8716(92)90063-I