Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector

A sensitive and selective method has been developed for the determination of sultopride and tiapride in serum using gas chromatography with a surface ionisation detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the stand...

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Bibliographic Details
Published in:Journal of chromatography. Biomedical applications 1991-06, Vol.567 (1), p.113-120
Main Authors: Kamizono, Ayako, Inotsume, Nobuo, Miyamoto, Kenshiro, Ueda, Keishi, Miyakawa, Taihei, Arimoto, Hiromi, Nakano, Masahiro
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:A sensitive and selective method has been developed for the determination of sultopride and tiapride in serum using gas chromatography with a surface ionisation detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the standard curve was linear up to 2 μg/ml with a correlation coefficient of 0.999. This method is applicable to pharmacokinetic studies and therapeutic drug monitoring of sultopride and tiapride.
ISSN:0378-4347
DOI:10.1016/0378-4347(91)80315-4