Simultaneous determination of ( R)- and ( S)-naproxen and ( R)- and ( S)-6-O-desmethylnaproxen by high-performance liquid chromatography on a Chiral-AGP column

A high-performance liquid chromatographic method for the simultaneous determination of both enantiomers of naproxen and its metabolite 6-O-desmethylnaproxen has been developed. The separation is performed on a column containing α 1-acid glycoprotein as the chiral selector. The method has been used f...

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Bibliographic Details
Published in:Journal of chromatography. Biomedical applications 1992-06, Vol.577 (2), p.362-365
Main Authors: Andersen, Jan Vanggaard, Hansen, Steen Honoré
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:A high-performance liquid chromatographic method for the simultaneous determination of both enantiomers of naproxen and its metabolite 6-O-desmethylnaproxen has been developed. The separation is performed on a column containing α 1-acid glycoprotein as the chiral selector. The method has been used for the determination of the enantiomeric purity of the drug substance and the metabolite, and for the simultaneous determination of all four compounds in biological fluids.
ISSN:0378-4347
DOI:10.1016/0378-4347(92)80260-W