Separation of fifteen non-steroidal anti-inflammatory drugs using micellar electrokinetic capillary chromatography

Micellar electrokinetic capillary chromatography with sodium dodecylsulfate as anionic surfactant was used to separate simultaneously fifteen non-steroidal anti-inflammatory drugs. UV detection was performed at 254 nm. The electroosmotic flow was carefully adjusted for optimal separation. Resolution...

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Bibliographic Details
Published in:Journal of chromatography. Biomedical applications 1994-07, Vol.657 (1), p.173-183
Main Authors: Maboundou, Chrysostome W., Paintaud, Gilles, Bérard, Michel, Bechtel, Pierre R.
Format: Article
Language:English
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Summary:Micellar electrokinetic capillary chromatography with sodium dodecylsulfate as anionic surfactant was used to separate simultaneously fifteen non-steroidal anti-inflammatory drugs. UV detection was performed at 254 nm. The electroosmotic flow was carefully adjusted for optimal separation. Resolution of the drugs was obtained using a buffer containing 40 mmol l −1 NaH 2PO 4, 0.104 mol l −1 sodium dodecylsulfate and 3% (v/v) methanol, adjusted to pH 8 with sodium hydroxide. Lack of interference was checked with a number of drugs and metabolites. Between-day coefficients of variation ranged between 2 to 10%.
ISSN:0378-4347
DOI:10.1016/0378-4347(94)80084-7