Physical characterization of carteolol: Eudragit® L binding interaction

Eudragit® L 30D was used as a carrier to prepare carteolol polymeric complexes in order to obtain controlled release dosage forms. The polyanionic form of the polymer, neutralized at different degrees, reacts readily with carteolol hydrochloride to give water-insoluble complexes. Carteolol complexes...

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Bibliographic Details
Published in:International journal of pharmaceutics 1995-01, Vol.114 (1), p.13-21
Main Authors: Holgado, Maria Angeles, Fernandez-Arevalo, Mercedes, Alvarez-Fuentes, Josefa, Caraballo, Isidoro, Llera, Jose Manuel, Rabasco, Antonio Maria
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carteolol hydrochloride
Complexation process
Eudragit® L 30D
General pharmacology
Glass transition temperature
Hydrogen bond interaction
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Saline bond interaction
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Summary:Eudragit® L 30D was used as a carrier to prepare carteolol polymeric complexes in order to obtain controlled release dosage forms. The polyanionic form of the polymer, neutralized at different degrees, reacts readily with carteolol hydrochloride to give water-insoluble complexes. Carteolol complexes were characterized by differential scanning calorimetry, IR, 1H- and 13C-NMR spectroscopy. In fact, results indicated that there were intermolecular associations between the polymer and the drug consisting in ammonium salt interactions. Maximum carteolol content was found to be 22% in the complexes.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(94)00208-M