Study of the dissolution characteristics of oxazepam via complexation with β-cyclodextrin

Complex formation of oxazepam and β-cyclodextrin in solution was studied by phase solubility and spectral shift methods. The value of the apparent stability constant, K c , calculated using these techniques, was 205 and 498 M −1, respectively. Solid complexes of oxazepam and β-CD were prepared using...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 1995-01, Vol.114 (1), p.95-102
Main Authors: Moyano, J.R., Ginés, J.M., Arias, M.J., Rabasco, A.M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Hypnotics. Sedatives
Inclusion complex
Kneading
Medical sciences
Neuropharmacology
Oxazepam
Pharmacology. Drug treatments
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Spray-drying
β-Cyclodextrin
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Complex formation of oxazepam and β-cyclodextrin in solution was studied by phase solubility and spectral shift methods. The value of the apparent stability constant, K c , calculated using these techniques, was 205 and 498 M −1, respectively. Solid complexes of oxazepam and β-CD were prepared using the kneading and spray-drying methods. These complexes led to an improvement in the dissolution rate over free oxazepam, spray-drying being the most efficient technique. These complexes were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray diffraction.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(94)00220-Y