A simulation model for the primary drying phase of the freeze-drying cycle

A lyophilization process model was adapted to fit experimental data from product vials processed using a development scale dryer. The model was evaluated with regard to how well it simulated the primary drying time and temperature conditions for product vials during the primary drying phase of the c...

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Bibliographic Details
Published in:International journal of pharmaceutics 1995-02, Vol.114 (2), p.159-170
Main Authors: Schoen, Marco P., Braxton, Bryan K., Gatlin, Larry A., Jefferis, Raymond P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Freeze-drying
General pharmacology
Mathematical model
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Primary drying temperature
Primary drying time
Simulation
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Summary:A lyophilization process model was adapted to fit experimental data from product vials processed using a development scale dryer. The model was evaluated with regard to how well it simulated the primary drying time and temperature conditions for product vials during the primary drying phase of the cycle. The results indicated the predicted drying time was very close to the actual drying time observed for the product. The simulated product temperature profile also compared well with the actual product temperature profile. The simulation results are presented as well as the coefficients used to fit the data.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(94)00234-V