Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients

Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ketoprofen with some excipients currently employed in tablet or capsule formulations. The effect of sample treatment (simple blending, cogrinding, compression, kneading) was also evaluated. O...

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Bibliographic Details
Published in:International journal of pharmaceutics 1995-05, Vol.119 (1), p.71-79
Main Authors: Mura, P., Manderioli, A., Bramanti, G., Furlanetto, S., Pinzauti, S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Compatibility
Drug-excipient interaction
DSC
General pharmacology
Ketoprofen
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Solid dosage form
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Summary:Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ketoprofen with some excipients currently employed in tablet or capsule formulations. The effect of sample treatment (simple blending, cogrinding, compression, kneading) was also evaluated. On the basis of DSC results, ketoprofen was found to be compatible with hydroxyethylcellulose, hydroxypropylcellulose, microcrystalline cellulose, corn starch, arabic gum, colloidal silica, veegum, lactose, glucose, sorbitol and mannitol. Some drug-excipient interaction was observed with palmitic acid, stearic acid and stearyl alcohol and eutectic formation was found with magnesium stearate. Strong solid-phase interaction with polyethylene glycol 6000, polyvinylpolypyrrolidone and even more with polyvinylpyrrolidone K30 was found.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(94)00374-E