Evaluation of the gastric behaviour of coevaporate particles under fasting and non-fasting conditions

The gastric emptying half-times of Eudragit® S- 111 In-oxinate coevaporate particles (fraction size, 0.10–0.50 mm; density, 1.36 g cm −3) were determined by gamma scintigraphy in both fasted and fed healthy volunteers. The mean gastric emptying half-times ± SD under fasting and non-fasting condition...

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Bibliographic Details
Published in:International journal of pharmaceutics 1995-08, Vol.123 (1), p.145-147
Main Authors: Beten, D.B., Van Gansbeke, B., Schoutens, A., Moës, A.J.
Format: Article
Language:English
Subjects:
111In-oxinate
Biological and medical sciences
Coevaporate
Eudragit® S
Gamma scintigraphy
Gastric emptying
General pharmacology
Medical sciences
Pellet
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
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Summary:The gastric emptying half-times of Eudragit® S- 111 In-oxinate coevaporate particles (fraction size, 0.10–0.50 mm; density, 1.36 g cm −3) were determined by gamma scintigraphy in both fasted and fed healthy volunteers. The mean gastric emptying half-times ± SD under fasting and non-fasting conditions were 67 ± 15 and 308 ± 53 min, respectively, indicating that gastric emptying of coevaporate particles is delayed in the presence of food to a greater extent than most pellets of normal density.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)00087-Y