Holographic evaluation of bending and integrity of pharmaceutical powder beams

Double-exposure holographic interferometry was used to detect structural uniformity and bending properties of compressed rectangular beams consisting of microcrystalline cellulose, dicalcium phosphate dihydrate and α-lactose monohydrate. The fringes in holographic reconstructions produced a clear pa...

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Bibliographic Details
Published in:International journal of pharmaceutics 1996-04, Vol.131 (2), p.209-217
Main Authors: Silvennoinen, Raimo, Raatikainen, Pasi, Ketolainen, Jarkko, Ketolainen, Pertti, Paronen, Petteri
Format: Article
Language:English
Subjects:
Beam bending
Biological and medical sciences
Double-exposure holographic interferometry
Elastic deformation
General pharmacology
Medical sciences
Pharmaceutical powders
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Specimen integrity
Young's modulus
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Summary:Double-exposure holographic interferometry was used to detect structural uniformity and bending properties of compressed rectangular beams consisting of microcrystalline cellulose, dicalcium phosphate dihydrate and α-lactose monohydrate. The fringes in holographic reconstructions produced a clear pattern for interpretation of bending without any complication. Thus, it was possible to calculate the elastic modulus values for both the upper and lower surfaces of the sample beams. The theoretical bending profiles versus experimental bending data were also evaluated. It was possible to detect unpredictable changes due, for example, to structural non-homogeneities and induced stress. The induced stress inside the beams had a slight effect on the ideal bending, due to the fixing of the beam. The modulus values obtained from extrapolation to zero porosity were in good agreement with the previously published results. According to this study, double-exposure holographic interferometry is a suitable, accurate and versatile method for mechanical studies of pharmaceutical powders and compacts.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)04329-2