Secondary x-ray fluorescence for in vivo transdermal absorption measurements

A modification of an X-ray fluorescence (XRF) technique that could be applied to the noninvasive measurement of transdermal absorption in human subjects with a low absorbed radiation dose was investigated. Secondary X-rays that were produced in a samarium foil by an isotopic 241Am source were used t...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 1996-04, Vol.131 (2), p.243-246
Main Authors: MacLean, Donald S., Robertson, J.David, Moody, Edward, Stalker, Dennis J., Jay, Michael
Format: Article
Language:English
Subjects:
5-Chloro-7-iodo-8-hydroxyquinoline
Biological and medical sciences
General pharmacology
In vivo percutaneous absorption
Medical sciences
Noninvasive
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Topical delivery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A modification of an X-ray fluorescence (XRF) technique that could be applied to the noninvasive measurement of transdermal absorption in human subjects with a low absorbed radiation dose was investigated. Secondary X-rays that were produced in a samarium foil by an isotopic 241Am source were used to induce iodine Kα X-rays in an iodine-containing compound. The disappearance of this compound was measured following topical administration to a human volunteer. The use of the secondary X-ray fluorescence technique resulted in an 11-fold reduction in the absorbed radiation dose to the skin compared to conventional XRF bringing the technique within acceptable dosimetry limits for human studies.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)04345-4