In vitro retinoic acid release and skin permeation from different liposome formulations

The effect of including charged phospholipids (both negative and positive) and/or cholesterol in liposomal formulations on retinoic acid (RA) in vitro release and permeation through human stratum corneum and epidermis was studied. No significant difference in RA release was observed comparing the di...

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Bibliographic Details
Published in:International journal of pharmaceutics 1996-05, Vol.133 (1), p.89-96
Main Authors: Montenegro, Lucia, Panico, Anna Maria, Ventimiglia, Antonino, Bonina, Francesco P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Charged phospholipids
In vitro
Liposomes
Medical sciences
Pharmacology. Drug treatments
Release
Retinoic acid
Skin permeation
Skin, nail, hair, dermoskeleton
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Summary:The effect of including charged phospholipids (both negative and positive) and/or cholesterol in liposomal formulations on retinoic acid (RA) in vitro release and permeation through human stratum corneum and epidermis was studied. No significant difference in RA release was observed comparing the different liposomal formulations tested. On the contrary, positively charged liposomes provided significantly higher RA skin permeation compared to negatively charged vesicles which, in turn, showed RA permeation through the skin similar to that obtained from neutral liposomes. Furthermore, the inclusion of cholesterol in charged liposomes did not significantly affect RA skin permeation.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)04422-1