The release of clindamycin phosphate from a suspension of different types of liposomes and selected topical dosages forms

A Franz diffusion cells system was used to determine the release rate profile of clindamycin phosphate. Different types of liposomes containing clindamycin phosphate were prepared and the steady-state release of the drug, through a semipermeable synthetic membrane, was determined. The highest retent...

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Bibliographic Details
Published in:International journal of pharmaceutics 1996-05, Vol.134 (1), p.71-77
Main Authors: Arnardóttir, H.B., Sveinsson, S.J., Kristmundsdóttir, T.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Clindamycin phosphate
Dermal drug delivery
Franz diffusion cell
Liposomes
Medical sciences
Pharmacology. Drug treatments
Steady-state flux
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Summary:A Franz diffusion cells system was used to determine the release rate profile of clindamycin phosphate. Different types of liposomes containing clindamycin phosphate were prepared and the steady-state release of the drug, through a semipermeable synthetic membrane, was determined. The highest retention of clindamycin phosphate was seen from a suspension of multilamellar liposomes containing 1% clindamycin phosphate. Hydrogels, of acceptable consistency for topical use, were developed and used as carriers for a suspension of reverse-phase liposomes containing clindamycin phosphate. Increased penetration of clindamycin phosphate through a hairless mouse skin from a liposomes-containing vehicle compared with the permeation of the drug in a phosphate buffer was not observed.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(96)04437-7