Degradation kinetics of α-tocopherol in hydrophilic gels

The present work studies the degradation kinetics of α-tocopherol in hydrophilic gels incorporating vitamin C as antioxidant. HPLC was used to detect the amounts of α-tocopherol remaining and to validate the analytical and extraction techniques. The results indicate that α-tocopherol undergoes degra...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 1996-08, Vol.140 (2), p.251-255
Main Authors: Lucero, M.J., Vigo, J., León, M.J.
Format: Article
Language:English
Subjects:
Antioxidant
Ascorbic acid
Biological and medical sciences
Carbomer ®940
General and cellular metabolism. Vitamins
Medical sciences
Oxidation
Pharmacology. Drug treatments
αtocopherol
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present work studies the degradation kinetics of α-tocopherol in hydrophilic gels incorporating vitamin C as antioxidant. HPLC was used to detect the amounts of α-tocopherol remaining and to validate the analytical and extraction techniques. The results indicate that α-tocopherol undergoes degradation by oxidation of the hydroxyl group, and that this is reduced by the presence of the antioxidant.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(96)04608-X