Radiosterilization dosimetry by ESR spectroscopy: Application to terbutaline

The use of ionizing radiation for sterilization of pharmaceuticals is now a well established technology. The purpose of the present work was to apply the electron spin resonance (ESR) spectroscopy to the irradiation dosimetry of terbutaline. Our preliminary work indicates that: - evaluation of the i...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pharmaceutics 1996-10, Vol.142 (2), p.247-249
Main Authors: Basly, J.P., Duroux, J.L., Bernard, M.
Format: Article
Language:English
Subjects:
Bi-exponential regression
Biological and medical sciences
Electron spin resonance
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polynomial regression
Terbutaline hydrochloride
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of ionizing radiation for sterilization of pharmaceuticals is now a well established technology. The purpose of the present work was to apply the electron spin resonance (ESR) spectroscopy to the irradiation dosimetry of terbutaline. Our preliminary work indicates that: - evaluation of the irradiation dose could be possible by post-irradiation using a polynomial regression; - the decay of radicals upon storage could be simulated by a bi-exponential regression; discrimination of irradiated drugs from unirradiated ones could be possible even after a storage greater than 3 years.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(96)04661-3