Remote synthesis of [ 11C]acetate

This remote synthesis greatly simplifies previously reported liquid—liquid extraction techniques for remote production of [ 11C]acetate. The use of solid phase extraction has reduced the total volume of solvents employed while providing [ 11C]acetate free of labeled by-products. Remotely actuated lo...

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Bibliographic Details
Published in:International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1992, Vol.43 (7), p.943-945
Main Authors: Norenberg, J.P., Simpson, N.R., Dunn, B.B., Kiesewetter, D.O.
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Labelled compounds chemistry
Organic chemistry
Reactivity and mechanisms
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Summary:This remote synthesis greatly simplifies previously reported liquid—liquid extraction techniques for remote production of [ 11C]acetate. The use of solid phase extraction has reduced the total volume of solvents employed while providing [ 11C]acetate free of labeled by-products. Remotely actuated loop flow valves have been utilized to efficiently and quickly introduce reagents. [ 11C]Acetate is obtained within 15 min from the end of bombardment in 43% (EOB) radiochemical yield and with radiochemical purity >98%.
ISSN:0883-2889
DOI:10.1016/0883-2889(92)90162-8