Insertional mutation of the motor endplate disease ( med) locus on mouse chromosome 15

Homozygous transgenic mice from line A4 have an early-onset progressive neuromuscular disorder characterized by paralysis of the rear limbs, muscle atrophy, and lethality by 4 weeks of age. The transgene insertion site was mapped to distal chromosome 15 close to the locus motor endplate disease ( me...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1995-03, Vol.26 (2), p.171-177
Main Authors: Kohrman, David C., Plummer, Nicholas W., Schuster, Timothy, Jones, Julie M., Jang, Wonhee, Burgess, Daniel L., Galt, James, Spear, Brett T., Meisler, Miriam H.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Calcium-Binding Proteins
Cell Adhesion Molecules, Neuronal
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Contactin 1
Contactins
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Invertebrata
Membrane Glycoproteins - genetics
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Knockout
Mice, Neurologic Mutants
Molecular Sequence Data
Motor Endplate - pathology
Mutagenesis, Insertional
Nerve Tissue Proteins - genetics
Neuromuscular Diseases - genetics
Purkinje Cells - pathology
Sequence Deletion
Synaptotagmin I
Synaptotagmins
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Description
Summary:Homozygous transgenic mice from line A4 have an early-onset progressive neuromuscular disorder characterized by paralysis of the rear limbs, muscle atrophy, and lethality by 4 weeks of age. The transgene insertion site was mapped to distal chromosome 15 close to the locus motor endplate disease ( med). The sequence of mouse DNA flanking the insertion site junctions was determined. A small (
ISSN:0888-7543
1089-8646
DOI:10.1016/0888-7543(95)80198-U