Fluvoxamine increases the clozapine serum levels significantly

In this case report we describe an interaction between clozapine and fluvoxamine in two physically healthy patients meeting the DSM-IIIR criteria for paranoid schizophrenia. The substantial rise of clozapine serum levels suggest that caution should be exercised when combining fluvoxamine with clozap...

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Bibliographic Details
Published in:European neuropsychopharmacology 1996-03, Vol.6 (1), p.69-71
Main Authors: Koponen, Hannu J., Leinonen, Esa, Lepola, Ulla
Format: Article
Language:English
Subjects:
Adult
Clozapine
Clozapine - blood
Clozapine - therapeutic use
Drug Interactions
Fluvoxamine
Fluvoxamine - pharmacology
Humans
Male
Schizophrenia - drug therapy
Serum drug concentration
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Summary:In this case report we describe an interaction between clozapine and fluvoxamine in two physically healthy patients meeting the DSM-IIIR criteria for paranoid schizophrenia. The substantial rise of clozapine serum levels suggest that caution should be exercised when combining fluvoxamine with clozapine as the clozapine concentration may increase by a factor of 5–10.
ISSN:0924-977X
1873-7862
DOI:10.1016/0924-977X(95)00069-2