Antagonism of 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain by 1-piperonylpiperazine

• Published in: European journal of pharmacology 1992-09, Vol.228 (2), p.171-174
• Main Authors: HASHIMOTO, K, MAEDA, H, GOROMARU, T
• Format: Article
• Language: English
• Subjects: 1-Piperonylpiperazine; 3,4-Methylenedioxyamphetamine - analogs & derivatives; 3,4-Methylenedioxyamphetamine - antagonists & inhibitors; 3,4-Methylenedioxyamphetamine - toxicity; 3,4-methylenedioxymethamphetamine; 5-HT; 5-HT uptake inhibitor; 5-hydroxytryptamine; Animals; Biological and medical sciences; Brain (rat); Brain - drug effects; Brain - metabolism; Drug toxicity and drugs side effects treatment; Hydroxyindoleacetic Acid - metabolism; Injections, Intraperitoneal; Male; MDMA; Medical sciences; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity; Pharmacology. Drug treatments; Piperazines - pharmacology; Quipazine - analogs & derivatives; Quipazine - pharmacology; Rats; Rats, Wistar; serotonin; Serotonin - metabolism; Serotonin Antagonists - pharmacology; Serotonin Uptake Inhibitors - pharmacology; Toxicity: nervous system and muscle
• ISSN: 0926-6917; 0014-2999
• DOI: 10.1016/0926-6917(92)90027-A

The effects of 1-piperonylpiperazine and N,α-dimethylpiperonylamine, which are weak inhibitors for [ 3H]5-hydroxytryptamine (5-HT) uptake, on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity were examined. The reductions of serotonergic parameters in the rat cerebral cortex produced by multiple administration of MDMA (10 mg/kg) were attenuated significantly by coadministration of 6-nitroquipazine (10 mg/kg), paroxetine (10 mg/kg) or 1-piperonylpiperazine (20 mg/kg), but not by N,α-dimethylpiperonylamine (20 mg/kg). The present data suggest that 1-piperonylpiperazine might inhibit the MDMA-induced neurotoxicity by effect(s) other than 5-HT uptake inhibition.