Influence of different glycosphingolipids on the conductometric properties of a model phospholipid membrane system

The conductometric properties of aqueous solutions of liposomes built up by inserting different gangliosides at different concentrations in a phospholipid bilayer have been investigated in the ratio frequency region, where the alteration of the electrical surface polarization produced in the membran...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 1996-07, Vol.7 (1), p.39-46
Main Authors: Cametti, C., De Luca, F., Macrì, M.A., Maraviglia, B., Misasi, R., Sorice, M., Pavan, A., Garofalo, T., Pontieri, G.M., Bordi, F., Zimatore, G.
Format: Article
Language:English
Subjects:
Conductometric properties
Gangliosides
Liposomes
Phospholipid membrane
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Summary:The conductometric properties of aqueous solutions of liposomes built up by inserting different gangliosides at different concentrations in a phospholipid bilayer have been investigated in the ratio frequency region, where the alteration of the electrical surface polarization produced in the membrane structure by the ganglioside insertion can be properly observed. We have studied a series of gangliosides (GM1, GM2, GM3, GD1a, GD1b, aGM1) characterized by the same hydrophobic part but with different hydrophilic portions. The results show a quite complex conductivity behaviour that can be only partially accounted for in terms of a surface conductance contribution. Some phenomenological correlations between the hydrophilic head group structure and the electrical conductivity behaviour are presented.
ISSN:0927-7765
1873-4367
DOI:10.1016/0927-7765(96)01280-5