Synthesis, structure and antiaggregatory effects of some α-hydroxy analogues of 2-aryliminoimidazolines in human platelets

Title compounds 3a-i were obtained from the reaction of 2-chloro-4,5-dihydroimidazole 1 and suitable N-arylhydroxylamines 2. Crystal and molecular structure of the 3-methyl derivative 3b was determined. To gain an understanding of the significance of α-hydroxy group in the 2-aryl-iminoimidazolines,...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 1996-03, Vol.4 (2), p.85-93
Main Authors: Saczewski, Franciszek, Debowski, Tomasz, Gdaniec, Maria, Petrusewicz, Jacek, Turowski, Maciej, Damasiewicz, Barbara
Format: Article
Language:English
Subjects:
Chemical synthesis
Platelet aggregation inhibitors
α-hydroxy-2-aryliminoimidazolines
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Summary:Title compounds 3a-i were obtained from the reaction of 2-chloro-4,5-dihydroimidazole 1 and suitable N-arylhydroxylamines 2. Crystal and molecular structure of the 3-methyl derivative 3b was determined. To gain an understanding of the significance of α-hydroxy group in the 2-aryl-iminoimidazolines, compounds 3a-i were studied as potential inhibitors of the blood platelet aggregation induced by adrenaline.
ISSN:0928-0987
1879-0720
DOI:10.1016/0928-0987(95)00035-6