Efficient pathways to ( R)- and ( S)-5-hydroxymethyl-2-oxazolidinone and some derivatives

2-Oxazolidinones are a very interesting class of compounds due to their various pharmacological effects. Two new syntheses of enantiomerically pure ( R)- and ( S)-5-hydroxymethyl-2-oxazolidinone have been developed starting with D-mannitol, L-ascorbic acid and ( R)- or ( S)-malic acid. ( R)- and ( S...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1995, Vol.6 (5), p.1181-1190
Main Authors: Danielmeier, Karsten, Steckhan, Eberhard
Format: Article
Language:English
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Summary:2-Oxazolidinones are a very interesting class of compounds due to their various pharmacological effects. Two new syntheses of enantiomerically pure ( R)- and ( S)-5-hydroxymethyl-2-oxazolidinone have been developed starting with D-mannitol, L-ascorbic acid and ( R)- or ( S)-malic acid. ( R)- and ( S)-5-hydroxymethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/0957-4166(95)00144-E