682 Loco-regional recurrences in a randomized trial of breast cancer TNM stage II—prognostic factors

• Published in: European journal of cancer (1990) 1995-11, Vol.31, p.S143-S143
• Main Authors: Tennvall-Nittby, L., Tengrup, I.
• Format: Article
• Language: English
• ISSN: 0959-8049; 1879-0852
• DOI: 10.1016/0959-8049(95)95932-V

Loco-regional recurrence (LR) was studied in 1153 patients with breast cancer all operated with modified mastectomy and randomized into 6 adjuvant treatment groups thus: Premenopausal patients RT and/or Cyklophosphamide; post-menopausal patients RT and/or Tamoxifen. Median observation time 12 years. Recurrence occurred in a total of 460 patients, 128 of whom had LR ± distant metastases. The distribution between T1/T2 tumours did not differ in patients with LR compared with the total material. However, premenopausal patients without postoperative RT, with LR had more T2 tumours (83% vs 61%). Patients with LR had significantly more N+tumours initially compared with the patients in the total study. However, premenopausal patients without postoperative RT did not differ from the patients in the whole study regarding the distribution between N0 and N+. Premenopausal patients in the total study had significantly more tumours of ductal carcinoma of comedo type compared with the postmenopausal patients (48% vs 35%). Premenopausal patients without postoperative RT with LR had more often tumours of comedo type than those with postoperative RT (61% vs 41%). Postmenopausal patients with or without postoperative RT with LR had significantly more tumours of comedo type than those in the total study (57% vs 35%). Patients with first local recurrence and without progressive disease had a high proportion of lobular tumours (33%), compared with the total study (9%) and all LR (7%). Unfavourable prognostic factors for developing LR were found in this study to be positive lymph nodes and in postmenopausal patients tumours ofcomedo type.