Indolocarbazoles.3. Synthesis of novel aza analogs of staurosporine and K 252a as PKC inhibitors

Indolocarbazole 4 and arcyriaflavin A 19 reacted under basic conditions with 1-benzyl-2,6-bis (benzotriazolyl)-piperidine to give 5 and 20. As an extension of this methodology other related bis benzotriazole derivatives were synthesized and coupled with 19 to obtain a variety of aza derivatives 3. N...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1994-02, Vol.4 (3), p.495-498
Main Authors: Shankar, B.B., Viet, A.Q., Rizvi, R., Kirkup, M.P., McCombie, S.W., Ganguly, A.K.
Format: Article
Language:English
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Summary:Indolocarbazole 4 and arcyriaflavin A 19 reacted under basic conditions with 1-benzyl-2,6-bis (benzotriazolyl)-piperidine to give 5 and 20. As an extension of this methodology other related bis benzotriazole derivatives were synthesized and coupled with 19 to obtain a variety of aza derivatives 3. N-dbenzylation of these compounds gave novel PKC inhibitors. Indolocarbazole 4 and arcyriaflavin A 19 reacted under basic conditions with 1-benzyl-2,6-bis (benzotriazolyl) piperidine derivatives to provide a variety of aza derivatives 3. N-debenzylation of these compounds gave novel PKC inhibitors.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(94)80024-3