Hydroxamate inhibitors of human gelatinase B (92 kDa)

Gelatinase B is potently inhibited by peptide hydroxamates, including molecules that have a R 1′ group which is larger than the side chains of the natural amino acids. Gelatinase B is potently inhibited by peptide hydroxamates, including molecules that have a R 1' group which is larger than the...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-02, Vol.5 (4), p.349-352
Main Authors: Wahl, Robert C., Pulvino, Tricia A., Mathiowetz, Alan M., Ghose, Arup K., Johnson, Jeffrey S., Delecki, Daniel, Cook, Ewell R., Gainor, James A., Gowravaram, Madhusudhan R., Tomczuk, Bruce E.
Format: Article
Language:English
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Summary:Gelatinase B is potently inhibited by peptide hydroxamates, including molecules that have a R 1′ group which is larger than the side chains of the natural amino acids. Gelatinase B is potently inhibited by peptide hydroxamates, including molecules that have a R 1' group which is larger than the side chains of the natural amino acids.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00033-P