CD45 protein tyrosine phosphatase: Determination of minimal peptide length for substrate recognition and synthesis of some tyrosine-based electrophiles as potential active-site directed irreversible inhibitors

Using fyn PTK as a template, a series of phosphopeptides 1–11 spanning in length from 1–14 amino acids was prepared. Kinetic evaluation of 1–11 suggest that CD45 does not have a strong preference for its N- or C-terminal amino acids and that extended phosphopeptides are not required for efficient su...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-02, Vol.5 (4), p.353-356
Main Authors: Bobko, Mark, Wolfe, Henry R., Saha, Ashis, Dolle, Roland E., Fisher, Diana K., Higgins, Terry J.
Format: Article
Language:English
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Summary:Using fyn PTK as a template, a series of phosphopeptides 1–11 spanning in length from 1–14 amino acids was prepared. Kinetic evaluation of 1–11 suggest that CD45 does not have a strong preference for its N- or C-terminal amino acids and that extended phosphopeptides are not required for efficient substrate turnover.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00034-Q