Preparation and in vitro activity of aryl ether derivatives of the FK-506 related immunosuppressive macrolides ascomycin and L-683,742

The arylation of the immunosuppressive macrolides ascomycin and L-683,742 using pentavalent bismuth reagents is described. The in vitro activities of the aryl ether analogs are reported. The C32-O-aryl ethers of the immunosuppressive macrolides ascomycin and L-683,742 were prepared using pentavalent...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-05, Vol.5 (10), p.1035-1038
Main Authors: Sinclair, Peter J., Wong, Frederick, Wyvratt, Matthew, Staruch, Mary Jo, Dumont, Francis
Format: Article
Language:English
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Summary:The arylation of the immunosuppressive macrolides ascomycin and L-683,742 using pentavalent bismuth reagents is described. The in vitro activities of the aryl ether analogs are reported. The C32-O-aryl ethers of the immunosuppressive macrolides ascomycin and L-683,742 were prepared using pentavalent bismuth reagents. The in vitro activities of the aryl ether analogs as measured in a T cell proliferation assay are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00161-L