A single precursor approach to new DNA cleaving and crosslinking agents

It is demonstrated that aryl diamine 1, designed after a d(A·T) specific minor groove binding agent, can serve as a precursor for the synthesis of two DNA cleaving (bisdiazonium 2 and bisazoester 5) and one crosslinking (bisazide 7) agents and, to this end, the present strategy is introduced as a co...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-06, Vol.5 (11), p.1191-1196
Main Authors: Jebaratnam, David J., Arya, Dev P., Chen, Hang, Kugabalasooriar, S., Duc Vo
Format: Article
Language:English
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Summary:It is demonstrated that aryl diamine 1, designed after a d(A·T) specific minor groove binding agent, can serve as a precursor for the synthesis of two DNA cleaving (bisdiazonium 2 and bisazoester 5) and one crosslinking (bisazide 7) agents and, to this end, the present strategy is introduced as a convergent approach for the development of DNA targeted anticancer drugs. The aryl diamine 1 can serve as a precursor for two DNA cleaving (bisdiazonium 2 and bisazoester 3) and one crosslinking (bisazide 4) agents.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00193-W