Synthesis of thymidine dimers containing a new internucleosidic amide linkage and their incorporation into oligodeoxyribonucleotides

The synthesis of thymidine dimers 5a,b containing a chiral carbon in the propionamide internucleosidic linkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA and RNA as well as the resistence of the singl...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-08, Vol.5 (15), p.1647-1652
Main Authors: De Napoli, L., Iadonisi, A., Montesarchio, D., Varra, M., Piccialli, G.
Format: Article
Language:English
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Summary:The synthesis of thymidine dimers 5a,b containing a chiral carbon in the propionamide internucleosidic linkage is described. These new epimeric dimers were incorporated in oligodeoxyribonucleotides and the melting temperature (Tm) with complementary DNA and RNA as well as the resistence of the single strand against exonuclease were determined. The synthesis of thymidine dimers containing a chiral carbon in the propionamide internucleosidic linkage is described. These new epimeric dimers were incorporated in oligodeoxyribonuceotides and the melting temperature (Tm) with complementary DNA and RNA as well as the resistence of the single strand against exonuclease were determined.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00279-3