17β-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase

Structure-function studies on the natural product wortmannin have identified a 17β-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingl...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-08, Vol.5 (15), p.1713-1718
Main Authors: Dodge, Jeffrey A., Bryant, Henry U., Kim, John, Matter, William F., Norman, Bryan H., Srinivasan, Usha, Vlahos, Chris J., Sato, Masahiko
Format: Article
Language:English
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Summary:Structure-function studies on the natural product wortmannin have identified a 17β-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption and phosphatidylinositol-3-kinase inhibition were also observed. Structure-function studies on the natural product wortmannin (1) have identified a 17β-hydroxy derivative as a potent inhibitor of osteoclast function in both cell and animal models. Mechanistic studies indicate osteoclast differentiation is dramatically affected by this class of compounds. Interestingly, comparable potency trends for resorption and phosphatidylinositol-3-kinase inhibition were also observed.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00291-Z