Synthesis of new azino fused benzimidazolium salts. a new family of DNA intercalating agents. I

A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1995-12, Vol.5 (24), p.3043-3048
Main Authors: Pastor, Joaquín, Siró, Jorge, García-Navío, JoséL., Vaquero, Juan J., Melia Rodrigo, M., Ballesteros, Milagros, Alvarez-Builla, Julio
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are a new family of intercalating agents. A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been obtained from commercial or readily available 1,3-disubstitued 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity have been tested. They are a new family of intercalating agents.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00532-4