Synthesis of water-soluble prodrugs of the cytotoxic agent Combretastatin A4

Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 ( 1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase. Water-soluble phosphate and glycine carbamate...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-01, Vol.6 (2), p.157-160
Main Authors: Bedford, Simon B, Quarterman, Charmaine P, Rathbone, Daniel L, Slack, John A, Griffin, Roger J, Stevens, Malcolm FG
Format: Article
Language:English
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Summary:Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 ( 1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase. Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 ( 1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(95)00580-M