Evaluation of tea polyphenols as anti-HIV agents

Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8- C-Ascorbyl (−)-epigallocatechin ( 13) and theasinensin-D ( 32) demonstrated relatively potent anti-HIV activity with EC 50 values of 4 and 8 μg/mL and therapeutic indexes of 9.5...

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Published in:Bioorganic & medicinal chemistry letters 1996-03, Vol.6 (6), p.695-700
Main Authors: Hashimoto, Fumio, Kashiwada, Yoshiki, Nonaka, Gen-ichiro, Nishioka, Itsuo, Nohara, Toshihiro, Cosentino, L.Mark, Lee, Kuo-Hsiung
Format: Article
Language:English
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Summary:Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8- C-Ascorbyl (−)-epigallocatechin ( 13) and theasinensin-D ( 32) demonstrated relatively potent anti-HIV activity with EC 50 values of 4 and 8 μg/mL and therapeutic indexes of 9.5 and 5, respectively. Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8- C-Ascorbyl (−)-epigallocatechin ( 13) and theasinensin-D ( 32) demonstrated relatively potent anti-HIV activity with EC 50 values of 4 and 8 μg/mL and therapeutic indexes of 9.5 and 5, respectively.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00095-9