Synthesis and antimicrobial activity of 4-amino trinems

This article deals with the study carried out on the synthesis of 4-amino substituted trinems 1 starting from the key-intermediate (3S, 4R)-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1′R, 2′S, 3′R)-1′,2′-epoxycyclohex-3′-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and s...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-07, Vol.6 (14), p.1683-1688
Main Authors: Tranquillini, Maria Elvira, Araldi, Gian Luca, Donati, Daniele, Pentassuglia, Giorgio, Pezzoli, Anna, Ursini, Antonella
Format: Article
Language:English
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Summary:This article deals with the study carried out on the synthesis of 4-amino substituted trinems 1 starting from the key-intermediate (3S, 4R)-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-4-[(1′R, 2′S, 3′R)-1′,2′-epoxycyclohex-3′-yl]azetidin-2-one 2. In particular, epoxide opening with various amines and subsequent cyclization to the corresponding trinems were explored. Their synthesis and antimicrobial activity are reported. The synthesis of 4-amino substituted trinems 1 starting from the epoxy intermediate 2 is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00292-2