Identification and characterisation of an inhibitor of interleukin-8: a receptor based approach

Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a single subdomain was shown to inhibit IL-8 binding and to act as a functional antagonist. Ala-scan and truncation strategies identified key are...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-08, Vol.6 (15), p.1869-1874
Main Authors: Attwood, Michael R., Borkakoti, Neera, Bottomley, Gillian A., Conway, Elizabeth A., Cowan, Irene, Fallowfield, Amanda G., Handa, Balraj K., Jones, Philip S., Keech, Elizabeth, Kirtland, Stephen J., Williams, Glyn, Wilson, Francis X.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a single subdomain was shown to inhibit IL-8 binding and to act as a functional antagonist. Ala-scan and truncation strategies identified key areas of this peptide for further work.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00331-9