Remarkable hydrolysis of phosphodiester by neutral lanthanide(III) DO3A complexes

The hydrolysis of the 4-nitrophenyl phosphate ester of propylene glycol (HPNP) is catalyzed by neutral lanthanide(III) DO3A complexes. Hydrolysis experiments with complexes of modified ligands where the metal complex was positively charged did not yield in a significant increase of the rate constant...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-09, Vol.6 (17), p.2063-2068
Main Authors: Kalesse, Markus, Loos, Andrea
Format: Article
Language:English
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Summary:The hydrolysis of the 4-nitrophenyl phosphate ester of propylene glycol (HPNP) is catalyzed by neutral lanthanide(III) DO3A complexes. Hydrolysis experiments with complexes of modified ligands where the metal complex was positively charged did not yield in a significant increase of the rate constant. Neutral Lanthanide(III)complexes are capable of hydrolyzing the 4-nitrophenyl phosphate ester of propylene glycol.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00386-1