Adenosine deaminase inhibitors. Synthesis and biological evaluation of chain modified analogs of (+)-EHNA

Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme. Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. Th...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-10, Vol.6 (20), p.2417-2420
Main Authors: Pragnacharyulu, Palle V.P., Lu, Pei-Jung, Abushanab, Elie
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme. Unsaturated chain modified analogs of (+)-EHNA have been prepared and evaluated as inhibitors of adenosine deaminase. The geometry appears to play a role in binding to the enzyme.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00439-8