Cryoradiation sterilization—Contemporary state and outlook

The new approach of radiation sterilization — cryoradiosterilization with programmed freezing — was developed for pharmaceutical solutions. Both scientific and technical problems are solved, the results are discussed. Programmed freezing of vials with the drug's solutions provides the high stab...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 1995-10, Vol.46 (4), p.633-637
Main Authors: Talrose, V.L., Trofimov, V.I.
Format: Article
Language:English
Subjects:
influenza
insulin
microbes
Radiation
sterilization
VIH
virus
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Summary:The new approach of radiation sterilization — cryoradiosterilization with programmed freezing — was developed for pharmaceutical solutions. Both scientific and technical problems are solved, the results are discussed. Programmed freezing of vials with the drug's solutions provides the high stability of soluted components with biological activity at sterilizing irradiation without significant change of sterilization doses. Physical, chemical, biological and pharmacological properties of a lot of drug solutions for injection satisfy official requirements after cryoradiation sterilization treatment. This method seems to be especially important for the protein systems which could be infected by dangerous viruses (VIH, hepatitis B): blood plasma, diagnostic sera, protein preparations manufactured from donor's blood, etc.
ISSN:0969-806X
1879-0895
DOI:10.1016/0969-806X(95)00232-M