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Comparative determination of photodegradation kinetics of quinolones
The photostabilities of several quinolones have been determined using high performance thin layer chromatography. On irradiation with UVA (350 nm), the photostability decreases in the order: ciprofloxacin (CP)> norfloxacin (NF) > pipemidic acid (PA) > nalidixic acid (NA) > M-193324 >...
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Published in: | Journal of photochemistry and photobiology. A, Chemistry. Chemistry., 1993-07, Vol.73 (2), p.135-138 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The photostabilities of several quinolones have been determined using high performance thin layer chromatography. On irradiation with UVA (350 nm), the photostability decreases in the order: ciprofloxacin (CP)> norfloxacin (NF) > pipemidic acid (PA) > nalidixic acid (NA) > M-193324 > rosoxacin (RS) > oxolinic acid (OA). The photo- degradation process in all cases follows first-order kinetics. Furthermore, the quantum yield of fluorescence was determined for each quinolone; these values vary from 0.15 x 10
−2 to 5.15 x 10
−2. The highest Φ
f value corresponds to CP and NF. These results show that quinolones which possess a piperazine ring at the C-7 position (CP, NF, PA) are less photostable and more fluorescent. |
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ISSN: | 1010-6030 1873-2666 |
DOI: | 10.1016/1010-6030(93)80042-8 |