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Comparative determination of photodegradation kinetics of quinolones

The photostabilities of several quinolones have been determined using high performance thin layer chromatography. On irradiation with UVA (350 nm), the photostability decreases in the order: ciprofloxacin (CP)> norfloxacin (NF) > pipemidic acid (PA) > nalidixic acid (NA) > M-193324 >...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. A, Chemistry. Chemistry., 1993-07, Vol.73 (2), p.135-138
Main Authors: Hidalgo, M.E., Pessoa, C., Fernández, E., Cárdenas, A.M.
Format: Article
Language:English
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Summary:The photostabilities of several quinolones have been determined using high performance thin layer chromatography. On irradiation with UVA (350 nm), the photostability decreases in the order: ciprofloxacin (CP)> norfloxacin (NF) > pipemidic acid (PA) > nalidixic acid (NA) > M-193324 > rosoxacin (RS) > oxolinic acid (OA). The photo- degradation process in all cases follows first-order kinetics. Furthermore, the quantum yield of fluorescence was determined for each quinolone; these values vary from 0.15 x 10 −2 to 5.15 x 10 −2. The highest Φ f value corresponds to CP and NF. These results show that quinolones which possess a piperazine ring at the C-7 position (CP, NF, PA) are less photostable and more fluorescent.
ISSN:1010-6030
1873-2666
DOI:10.1016/1010-6030(93)80042-8