Effects of soman on norepinephrine uptake and electrically stimulated release from human uterine arteries

The effects of soman on the uptake and electrically induced release of norepinephrine (noradrenaline) from isolated human uterine artery have been investigated. Soman did not alter the uptake of norepinephrine by human uterine artery, but reduced the electrically induced release of norepinephrine fr...

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Bibliographic Details
Published in:Pharmacological research 1992-02, Vol.25 (2), p.181-185
Main Authors: Hu, Chad-Yu, Robinson, Casey P.
Format: Article
Language:English
Subjects:
Adult
Arteries - drug effects
Arteries - metabolism
Biological and medical sciences
Female
human uterine arteries
Humans
In Vitro Techniques
Medical sciences
Middle Aged
Norepinephrine - pharmacokinetics
norepinephrine release
norepinephrine uptake
Pesticides, fertilizers and other agrochemicals toxicology
soman
Soman - pharmacology
Toxicology
Tritium
Uterus - blood supply
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Summary:The effects of soman on the uptake and electrically induced release of norepinephrine (noradrenaline) from isolated human uterine artery have been investigated. Soman did not alter the uptake of norepinephrine by human uterine artery, but reduced the electrically induced release of norepinephrine from the artery. This reduced norepinephrine release may augment the fall in blood pressure induced by accumulated acetylcholine stimulating muscarinic receptors following cholinesterase inhibition.
ISSN:1043-6618
1096-1186
DOI:10.1016/1043-6618(92)91386-U