Hypertensive disorders in twin versus singleton gestations

• Published in: American journal of obstetrics and gynecology 2000-04, Vol.182 (4), p.938-942
• Main Authors: Sibai, Baha M., Hauth, John, Caritis, Steve, Lindheimer, Marshall D., MacPherson, Cora, Klebanoff, Mark, VanDorsten, J.Peter, Landon, Mark, Miodovnik, Menachem, Paul, Richard, Meis, Paul, Thurnau, Gary, Dombrowski, Mitchell, Roberts, James, McNellis, Donald
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Diseases of mother, fetus and pregnancy; Gestational hypertension; Gynecology. Andrology. Obstetrics; Medical sciences; preeclampsia; pregnancy outcome; Pregnancy. Fetus. Placenta; twins
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/S0002-9378(00)70350-4

Objective: This study was undertaken to compare rates and severity of gestational hypertension and preeclampsia, as well as perinatal outcomes when these complications develop, between women with twin gestations and those with singleton gestations. Study Design: This was a secondary analysis of prospective data from women with twin (n = 684) and singleton (n = 2946) gestations enrolled in two separate multicenter trials of low-dose aspirin for prevention of preeclampsia. End points were rates of gestational hypertension, rates of preeclampsia, and perinatal outcomes among women with hypertensive disorders. Results: Women with twin gestations had higher rates of gestational hypertension (relative risk, 2.04; 95% confidence interval, 1.60-2.59) and preeclampsia (relative risk, 2.62; 95% confidence interval, 2.03-3.38). In addition, women with gestational hypertension during twin gestations had higher rates of preterm delivery at both