Misoprostol is more efficacious for labor induction than prostaglandin E2, but is it associated with more risk?

Our purpose was to compare the efficacy and safety of misoprostol with dinoprostone (Prepidil) for labor induction. In a randomized, controlled trial of labor induction, patients were randomly assigned to receive either 50 microgram of intravaginal misoprostol every 4 hours or 0.5 mg of intracervica...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1999-06, Vol.180 (6 Pt 1), p.1543-1550
Main Authors: Kolderup, L, McLean, L, Grullon, K, Safford, K, Kilpatrick, S J
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Adult
Bradycardia - epidemiology
Cesarean Section
Dinoprostone - administration & dosage
Dinoprostone - adverse effects
Dinoprostone - therapeutic use
Female
Fetal Distress - epidemiology
Heart Rate, Fetal
Humans
Intensive Care, Neonatal
Labor, Induced
Misoprostol - administration & dosage
Misoprostol - adverse effects
Misoprostol - therapeutic use
Oxytocics - adverse effects
Oxytocics - therapeutic use
Pregnancy
Risk Factors
Time Factors
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Summary:Our purpose was to compare the efficacy and safety of misoprostol with dinoprostone (Prepidil) for labor induction. In a randomized, controlled trial of labor induction, patients were randomly assigned to receive either 50 microgram of intravaginal misoprostol every 4 hours or 0.5 mg of intracervical prostaglandin E2 every 6 hours. Eligibility criteria included gestation of >/=31 weeks, Bishop score
ISSN:0002-9378
DOI:10.1016/S0002-9378(99)70050-5