A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women

Objective: The primary objective was to detect a difference in time until the first recurrence of urinary tract infection during treatment with an estradiol-releasing silicone vaginal ring (Estring; Pharmacia & Upjohn, Inc, Uppsala, Sweden) compared with no estrogen treatment. The secondary obje...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1999-05, Vol.180 (5), p.1072-1079
Main Author: Eriksen, Bjarne C.
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Aged
Aged, 80 and over
Biological and medical sciences
Estradiol
Estradiol - administration & dosage
Estradiol - adverse effects
Estradiol - therapeutic use
Female
Genital system. Reproduction
Humans
Medical sciences
Middle Aged
Pharmacology. Drug treatments
postmenopausal women
Postmenopause
Recurrence
recurrent urinary tract infection
Urethra - pathology
Urinary Tract Infections - microbiology
Urinary Tract Infections - pathology
Urinary Tract Infections - prevention & control
urogenital atrophy
Uterine Hemorrhage
Vagina - pathology
vaginal ring
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Summary:Objective: The primary objective was to detect a difference in time until the first recurrence of urinary tract infection during treatment with an estradiol-releasing silicone vaginal ring (Estring; Pharmacia & Upjohn, Inc, Uppsala, Sweden) compared with no estrogen treatment. The secondary objective was to detect any differences in improvement of urethral and vaginal mucosal atrophy and in the subjective assessment of urogenital symptoms. The study also sought to detect a difference in decrease of vaginal pH to
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(99)70597-1