Anterior uveitis associated with latanoprost

Purpose: To report the association of anterior uveitis with the use of latanoprost. Methods: We studied four patients with complicated open-angle glaucoma who had anterior uveitis associated with the use of latanoprost. The uveitis was unilateral and occurred only in the eye receiving latanoprost in...

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Bibliographic Details
Published in:American journal of ophthalmology 1998-07, Vol.126 (1), p.37-41
Main Authors: Fechtner, Robert D., Khouri, Albert S., Zimmerman, Thom J., Bullock, John, Feldman, Robert, Kulkarni, Prasad, Michael, Andrew J., Realini, Tony, Warwar, Ronald
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Female
Glaucoma, Open-Angle - drug therapy
Glucocorticoids - therapeutic use
Humans
Intraocular Pressure - drug effects
Latanoprost
Male
Medical sciences
Middle Aged
Ophthalmic Solutions
Pharmacology. Drug treatments
Prednisolone - analogs & derivatives
Prednisolone - therapeutic use
Prostaglandins F, Synthetic - administration & dosage
Prostaglandins F, Synthetic - adverse effects
Toxicity: eye
Uveitis, Anterior - chemically induced
Uveitis, Anterior - drug therapy
Uveitis, Anterior - physiopathology
Visual Acuity
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Summary:Purpose: To report the association of anterior uveitis with the use of latanoprost. Methods: We studied four patients with complicated open-angle glaucoma who had anterior uveitis associated with the use of latanoprost. The uveitis was unilateral and occurred only in the eye receiving latanoprost in three patients. In one patient, latanoprost was used in both eyes, and the uveitis was bilateral. Four of five eyes had a history of prior inflammation and/or prior incisional surgery. All patients were rechallenged with the drug. Results: The uveitis improved after cessation of latanoprost with or without topical corticosteroids. It recurred after rechallenging with latanoprost in all eyes. Conclusion: There is a possible association between latanoprost and anterior uveitis. Topical prostaglandin analogs may be relatively contraindicated in patients with a history of uveitis or prior ocular surgery. This association may also be possible in eyes that have not had previous uveitis or incisional surgery.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(98)00071-3