Combined effect of dorzolamide and latanoprost on the rate of aqueous humor flow

PURPOSE: To determine whether latanoprost, an ocular hypotensive agent believed to enhance uveoscleral outflow of aqueous humor, augments the aqueous-suppressing effect of dorzolamide, a topical carbonic anhydrase inhibitor. METHODS: Twenty-four normal subjects underwent measurement of aqueous humor...

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Bibliographic Details
Published in:American journal of ophthalmology 1998-08, Vol.126 (2), p.191-196
Main Authors: Vanlandingham, Benjamin D, Brubaker, Richard F
Format: Article
Language:English
Subjects:
Adult
Aqueous Humor - drug effects
Aqueous Humor - physiology
Biological and medical sciences
Carbonic Anhydrase Inhibitors - administration & dosage
Carbonic Anhydrase Inhibitors - pharmacology
Double-Blind Method
Drug Synergism
Drug Therapy, Combination
Eye
Female
Fluorophotometry
Humans
Intraocular Pressure - drug effects
Latanoprost
Male
Medical sciences
Middle Aged
Ocular Hypotension - chemically induced
Ophthalmic Solutions
Pharmacology. Drug treatments
Prostaglandins F, Synthetic - administration & dosage
Prostaglandins F, Synthetic - pharmacology
Sulfonamides - administration & dosage
Sulfonamides - pharmacology
Thiophenes - administration & dosage
Thiophenes - pharmacology
Uvea - drug effects
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Summary:PURPOSE: To determine whether latanoprost, an ocular hypotensive agent believed to enhance uveoscleral outflow of aqueous humor, augments the aqueous-suppressing effect of dorzolamide, a topical carbonic anhydrase inhibitor. METHODS: Twenty-four normal subjects underwent measurement of aqueous humor flow by fluorophotometry to determine the flow with placebo, with dorzolamide, and with a combination of dorzolamide and latanoprost. RESULTS: The flow of aqueous humor was suppressed 13% by dorzolamide but not by latanoprost. Latanoprost did not augment the effect of dorzolamide on aqueous humor flow; latanoprost and dorzolamide had additive ocular hypotensive effects. CONCLUSIONS: The uveoscleral flow effect of latanoprost does not improve the aqueous-suppressing effect of dorzolamide, but the two drugs have additive ocular hypotensive effects.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(98)00155-X